Leaders Recommendations for HER2 testing in the UK

نویسندگان

  • I O Ellis
  • Barrett Lee
چکیده

Determining the HER2 status of breast carcinomas is a prerequisite for the use of the monoclonal antibody trastuzumab (Herceptin®), which has recently been licensed for the treatment of metastatic disease. This necessitates a test based on archival material. The preferred analyses are immunohistochemistry with fluorescent in situ hybridisation (FISH) as a follow up test for ambiguous results. Guidelines have been developed for standardised, well controlled procedures for the provision of reliable results. A group of three reference laboratories has been established to provide advice, quality assurance, and materials, where needed. (J Clin Pathol 2000;53:890–892)

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تاریخ انتشار 2000